We provide the highest quality choices to assist women with their reproductive health. Our objective is to provide high quality medical and preventive health care for our patients. Our Clinical Research Program offers comprehensive gynecologic, obstetrics, and wellness care for women, and participates in clinical research studies as a privately contracted entity. Faculty members also are involved in the training of residents and medical students.

Research Studies in Women’s Health

Wright State Physicians Research Department conducts clinical research studies and clinical research trials in women’s health issues such as pelvic pain, bladder pain, contraception, incontinence, blood disorders during pregnancy, surgical site infection, pre-eclampsia, endometriosis and polycystic ovary syndrome. These studies include industry- funded projects, externally funded grants as well as non-funded projects.

Active Research Studies

• • Endometriosis
  • Preeclampsia
  • Fetal and Neonatal Alloimmune Thrombocytopenia (for blood disorder)
  • Implantable Tibial Neuromodulation (for bladder incontinence)
  • Botox injection for Interstitial Cystitis (for bladder pain)

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Gynecology Studies

Endometriosis

Endometriosis occurs when the endometrial tissue that lines the uterus, the endometrium, grows outside of the uterus. It may grow on ovaries, fallopian tubes, the outer uterine wall, the intestines or other organs in the abdominal area. Each month, during the menstrual cycle, the endometrial tissue does not flow out the way it normally would from the uterus, and instead it continues to build up, causing irritation, inflammation and pain in the abdominal area.

Endometriosis is a chronic, inflammatory condition that affects women of childbearing age and is a frequently a debilitating condition that is associated with a range of symptoms. The most common symptoms are painful menses, and non-menstrual pelvic pain in between menstrual cycles.

You may qualify to participate in this research study if you:

• Are female, 18 to 49 years of age
• Have a surgical diagnosis of endometriosis
• Have moderate to severe endometriosis pain
• Do not have osteoporosis or other metabolic bone disease

You will receive all study related care at no cost to you. You may receive compensation for your time and travel.

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Obstetrics Studies

Fetal and Neonatal Alloimmune Thrombocytopenia (blood disorder)

This study is to assess the occurrence of HPA-1a alloimmunization in pregnant women. Neonatal alloimmune thrombocytopenia is a disease that affects babies in which the platelet count is decreased due the mother’s immune system.

You may qualify to participate in this research study if you:

• Are a pregnant female
• 18 years or older
• 10-14 weeks pregnant

There is no cost to participants.

Preeclampsia

Placental Exosomes Study
The purpose of this study is to get a better understanding of the development that leads to pre-eclampsia.

You may qualify to participate in this research study if you:

• Are a pregnant female
• 18-39 years of age
• diagnosed with pre-eclampsia

There is no cost to participants.

Placental Biopsy Study
The purpose of this study to determine how often the pre-eclampsia gene is found in placentas.

You may qualify to participate in this research study if you:

• Are a pregnant female
• 18-39 years of age
• diagnosed with preeclampsia

There is no cost to participants.

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Urogynecology Studies

Urogynocology is a branch of medicine concerned with urological problems affecting women, such as bladder incontinence, bladder pain and overactive bladder.

Implantable Tibial Neuromodulator for bladder Incontinence

The purpose of this study is to use the Implantable Tibial Neuromodulator to lessen bladder Incontinence.

You may qualify to participate in this research study if you:

• Are 18 years of age or older
• Are diagnosed with UUI (urge urinary incontinence) for at least 6 months

You will receive all study related care at no cost to you.
You may receive compensation for your time and travel.

Bladder Interstitial Cystitis

The objective of this study is to demonstrate the safety and efficacy of BOTOX 100 U in reducing bladder pain.

You may qualify to participate in this research study if you:

• Are female 18 – 75 years of age
• IC/BPS (incontinence/bladder pain syndrome) for at least 6 months
• Confirmed dominant bladder derived pain, without Hunner lesions

You will receive all study related care at no cost to you.
You may receive compensation for your time and travel.